Tissue Phenomics Blog

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Topics:  image analysis, clinical cancer research, immunoscore, biomarkers, prognostic biomarker, oncology

Featured Articles of The Month (April, 2014): The Value of Immunotherapy in Cancer Therapeutics

Apr 30, 2014 11:07:00 AM

Anitei, M.G. et al. Prognostic and Predictive Values of the Immunoscore in Patients with Rectal Cancer. Clin Cancer Res. 2014 Apr 1;20(7):1891-9. doi: 10.1158/1078-0432.CCR-13-2830.
PURPOSE: To determine whether the tumor immune infiltrate, as recently evaluated with the Immunoscore methodology, could be a useful prognostic marker in patients with rectal cancers. Read more

Ichimura, T. et al. Prognostic Significance of CD204-Positive Macrophages in Upper Urinary Tract Cancer. Ann Surg Oncol. 2014 Feb 4. [Epub ahead of print].
BACKGROUND: Evidence suggests that CD204-positive (CD204(+)) tumor-infiltrating macrophages are associated with aggressive behavior of various cancers; however, the clinical, pathological, and prognostic associations of tumor-infiltrating CD204(+) macrophages in urothelial cancer have not been reported. Read more

Jiao, J. et al. Cell-Type Specific Roles for COX-2 in UVB-induced Skin Cancer. Carcinogenesis. 2014 Feb 17. [Epub ahead of print].
In human tumors, and in mouse models, cyclooxygenase-2 (COX-2) levels are frequently correlated with tumor development/burden. In addition to intrinsic tumor cell expression, COX-2 is often present in fibroblasts, myofibroblasts and endothelial cells of the tumor microenvironment, and in infiltrating immune cells. Intrinsic cancer cell COX-2 expression is postulated as only one of many sources for prostanoids required for tumor promotion/progression. Read more

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