Immuno-oncology was a super-hot topic in 2016. Several thousand publications contributed to the scientific progress, so choosing the top 3 is a challenging undertaking. But there are a few common themes seen in many highly ranked publications: the use of the latest hard- and software to gain an improved mechanistic understanding, why immuno-oncology actually works, and guidance on how to both design and predict individual patient success of novel therapies.Read More
Anitei, M.G. et al. Prognostic and Predictive Values of the Immunoscore in Patients with Rectal Cancer. Clin Cancer Res. 2014 Apr 1;20(7):1891-9. doi: 10.1158/1078-0432.CCR-13-2830.
PURPOSE: To determine whether the tumor immune infiltrate, as recently evaluated with the Immunoscore methodology, could be a useful prognostic marker in patients with rectal cancers. Read more
Ichimura, T. et al. Prognostic Significance of CD204-Positive Macrophages in Upper Urinary Tract Cancer. Ann Surg Oncol. 2014 Feb 4. [Epub ahead of print].
BACKGROUND: Evidence suggests that CD204-positive (CD204(+)) tumor-infiltrating macrophages are associated with aggressive behavior of various cancers; however, the clinical, pathological, and prognostic associations of tumor-infiltrating CD204(+) macrophages in urothelial cancer have not been reported. Read more
Jiao, J. et al. Cell-Type Specific Roles for COX-2 in UVB-induced Skin Cancer. Carcinogenesis. 2014 Feb 17. [Epub ahead of print].
In human tumors, and in mouse models, cyclooxygenase-2 (COX-2) levels are frequently correlated with tumor development/burden. In addition to intrinsic tumor cell expression, COX-2 is often present in fibroblasts, myofibroblasts and endothelial cells of the tumor microenvironment, and in infiltrating immune cells. Intrinsic cancer cell COX-2 expression is postulated as only one of many sources for prostanoids required for tumor promotion/progression. Read more
Here is a recap of the most popular documents and tips you may have missed on the digital imaging workflow:
Digital Slide Scanner Comparison Chart
In the process of evaluating digital slide scanners? Definiens compared 6 scanners currently available on the market and put their specifications in a single document for easy review.
Access the Digital Slide Scanner Comparison Chart to learn more about what these scanners have to offer.
5 Tips for Tissue Preparation
Increase image quality and consistency with a few modifications to key tissue preparation steps in your imaging workflow. Download 5 Tips to Optimize Tissue Prep for Preclinical Image Analysis to learn about changes you can make today.
5 Myths of Image Analysis
There are many misconceptions and misunderstandings about image analysis that keep researchers and pathologists using inefficient or underperforming solutions in their drug discovery and development workflows.
Learn about the Top 5 Image Analysis Myths and the truth to getting the most out of your research.
Case Study: Unlocking the Secret of Cancer Immunotherapy
In this case study, scientists quantified the immune response with Definiens' image analysis by assessing immune cell quantity and location, termed the Immunoscore, to identify a better predictor of disease-free survival for colorectal cancer patients than traditional TNM tumor staging.
Download the Immunoscore case study to learn more about how the scientists used automated image analysis to assess immune response as a prognostic biomarker and how these results are being validated in a 30-site global clinical study.
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