Tissue Phenomics Blog

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Topics:  predictive test, image analysis, clinical trials, Immunotherapy, oncology, tumor microenvironment

Evaluation of the Tumor Microenvironment Using Image Analysis for Clinical Trials

May 8, 2017 7:30:00 AM

Advances in immunotherapy have dramatically changed the landscape for cancer researchers. With significant improvements in overall survival and recurrent free survival in some of the deadliest cancers, lives have been extended by years for some patients while other patients have not experienced benefit from immunotherapy treatment. For some cancer indications, such as non-small cell lung cancer, the FDA approved companion diagnostic test for PD-L1 by immunohistochemistry has predictive value on patient response. However, the test is not a perfect indicator of response as some PD-L1 negative patients will respond to therapy and, conversely, some PD-L1 positive patients will not. At the same time, the number of clinical trials examining immunotherapy and combination therapies with immunotherapy as a backbone has exceeded 1000 in 2017. The possibility of combination therapy brings many questions to light for the researcher and ultimately the physician on which therapy to choose, for how long, in what order and what potential combination. With these questions, comes the increasing need for predictive tests that can lead the physician to the right therapy at the right time.

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Topics:  Immunotherapy, immunoscore, immuno-oncology, cancer therapy

The Top 3 Major Contributions to Immuno-oncology in 2016

Feb 6, 2017 8:29:57 AM

Immuno-oncology was a super-hot topic in 2016. Several thousand publications contributed to the scientific progress, so choosing the top 3 is a challenging undertaking. But there are a few common themes seen in many highly ranked publications: the use of the latest hard- and software to gain an improved mechanistic understanding, why immuno-oncology actually works, and guidance on how to both design and predict individual patient success of novel therapies.

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Topics:  image analysis, Immunotherapy, immuno-oncology, tissue phenomics, real world evidence

Three reasons image analysis should be incorporated into your immunotherapy real-world evidence development strategy

Jan 9, 2017 5:00:00 AM

Clinical trials are extremely important to assess the safety and effectiveness of a new therapy or of a currently-available therapy in a new indication. However, there are a few drawbacks to clinical trials, such as:

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Topics:  image analysis, clinical trials, drug development, Immunotherapy, immuno-oncology, predictive biomarkers, cancer treatment

How Image Analysis Can Improve the Results of Drug Development and Clinical Trials

Dec 12, 2016 4:00:00 AM

In recent years there have been several potentially life-saving medications approved for cancer treatment, including targeted molecular entities and biologics such as Opdivo (nivolumab) and Keytruda (pembrolizumab). Oncology drugs remain a pharmaceutical priority and investments into cancer account for 30% of all pre-clinical and phase 1 clinical development expenditures. There is an impressive list of close to 800 drugs and vaccines currently in the industry-wide development pipeline, many with promising results in early-stage clinical trials. However by historical measures only 10% or fewer of these drugs will ever make it through FDA approval and become part of routine patient care.

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Topics:  Immunotherapy, immuno-oncology, cancer immunotherapy

Definiens’ Favorite Videos on Immunotherapy

Jun 13, 2016 6:57:52 AM

Cancer immunotherapy is cutting edge science and video is currently the most popular tool in digital media to learn and communicate. For the hot topic of Immunotherapy there are currently almost 400 thousand videos available on the web. For just Cancer Immunotherapy there are still more than 15 thousand. Who would have the patience to watch all these and find the best ones? We do. Four Definiens experts searched the web for their most favorite videos about cancer immunotherapy.  Check it out below.

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