Tissue Phenomics Blog

Tissue Datafication

Topics:  personalized medicine, big data, tissue phenomics, oncology, digital pathology, colorectal cancer

Towards Personalised Pathology Through Tissue Phenomics®

Sep 14, 2016 3:00:00 AM

Path to personalised medicine

Pathology is one of the main driving forces behind personalised or precision medicine. In fact it has always striven towards the accurate diagnosis and prognosis of a patient’s disease through the observation of tissue architecture under the microscope. Through the application of international staging guidelines, such as the Tissue, Node, Metastasis (TNM) system in the majority of cancers, pathologists are very good at predicting prognosis at the population scale but not so good at predicting a prognosis for the individual patient. For example, if a patient presents with stage II colorectal cancer (CRC) they are predicted to have 20-30% chance of succumbing to their disease. However, it is currently difficult to accurately identify if an individual patient will be within that 20-30% group.

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Topics:  image analysis, personalized medicine, tissue phenomics, data mining

Five Major Benefits of Tissue Phenomics®

Aug 8, 2016 3:00:00 AM

Seeing is believing – this is an important aspect of Tissue Phenomics, where cellular structures in tissue slides taken from patients are investigated in real space. Observing directly what type of structures form and what kind of interactions take place is in general of much higher value than concluding indirectly from other type of data. I experienced this factor very clearly thirty years ago when people speculated about the atomic structure on the surfaces of matter from indirect measurement. When we could, however, image atomic structures directly, it became obvious that most of those speculations were wrong. This is the reason why even for a genetic disease like cancer, genetic information could not push histology aside. Observing the structures and the interactions in tissue slides on the cell level enables insights into the disease of a specific person that is decisive and cannot be created otherwise. Tissue Phenomics builds upon histological information and pathologists’ knowledge and is by no means about replacing it. The mission is rather to gain an even deeper insight into biological processes detectable in cell structures for the enablement of new and successful treatments of patients and their specific diseases. In the beginning there was the question how far one can get with the Tissue Phenomics approach, or more concretely, how far can we go beyond what the experts already know today? What can be achieved when the computer investigates all kind of cell patterns in tissue and correlate them with biological and medical relevance and meaning, represented e.g. by clinical outcome? Today we know better.

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Topics:  image analysis, digital pathology, IHC, tissue-based diagnosis, tissue analysis

4 Reasons Why Image Analysis is Important

Jul 11, 2016 3:00:00 AM

Why_Image_Analysis_Infografik_160628.pngPathology has established itself as a decisive diagnostic discipline in precision medicine and in particular in oncology. This brings new expectations for the accuracy and reproducibility of tissue-based diagnosis, in particular, when quantification of clinically meaningful histomorphological features (“tissue phenes”) is essential to better predict patient outcome and response to treatment. Until recently traditional pathologic diagnosis has been regarded as the ground truth, a concept which is no longer sustainable in contemporary tissue-based biomarker research and clinical utility, particular with the emergence of innovative immunotherapies and their combinations.

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Topics:  Immunotherapy, immuno-oncology, cancer immunotherapy

Definiens’ Favorite Videos on Immunotherapy

Jun 13, 2016 6:57:52 AM

Cancer immunotherapy is cutting edge science and video is currently the most popular tool in digital media to learn and communicate. For the hot topic of Immunotherapy there are currently almost 400 thousand videos available on the web. For just Cancer Immunotherapy there are still more than 15 thousand. Who would have the patience to watch all these and find the best ones? We do. Four Definiens experts searched the web for their most favorite videos about cancer immunotherapy.  Check it out below.

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Topics:  symposium, tissue phenomics, Definiens

Definiens' International Symposium for Tissue Phenomics® - A Summary

May 25, 2016 7:30:00 PM

The International Symposium for Tissue Phenomics in Boston, focused on advancements in (immuno)-oncology research. Several recent achievements fuel the hope to turn cancer into a curable disease such as:

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