Tissue Phenomics Blog

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Topics:  Biomarker Discovery, prognostic tests, biomarkers, cancer diagnostics, companion diagnostics

The Key to Discover Your Next Biomarker

Mar 18, 2014 2:24:00 PM

Biomarkers are critical to pharmaceutical and diagnostic companies developing novel therapies and diagnostics for oncology. Being able to discover and validate the best biomarkers forms the basis of any successful cancer diagnostic test.

Types of cancer diagnostic tests

• Companion diagnostics for new therapies – this type of diagnostic test is used for patient stratification in clinical trials. Successful companion diagnostics at this stage of drug development can increase the medical value of a therapy by selecting for responders or excluding patients at risk for severe side effects. Thus, they can facilitate regulatory approval, while keeping clinical trials smaller and cost effective.

Companion diagnostics for existing drugs – this type of diagnostic test is developed after a cancer therapy has already been on the market in order to better select the right patients for the therapy. Successful companion diagnostics for existing drugs aim to reduce overall healthcare costs and the experience of unnecessary side effects by identifying patients that will benefit from treatment.

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Topics:  Biomarker Discovery, image analysis, Immunotherapy, immunoscore, digital pathology

Definiens’ Best Of 2013

Jan 9, 2014 1:34:00 AM

Here is a recap of the most popular documents and tips you may have missed on the digital imaging workflow:

Digital Slide Scanner Comparison Chart
In the process of evaluating digital slide scanners? Definiens compared 6 scanners currently available on the market and put their specifications in a single document for easy review.
Access the Digital Slide Scanner Comparison Chart to learn more about what these scanners have to offer.

5 Tips for Tissue Preparation
Increase image quality and consistency with a few modifications to key tissue preparation steps in your imaging workflow. Download 5 Tips to Optimize Tissue Prep for Preclinical Image Analysis to learn about changes you can make today.

5 Myths of Image Analysis
There are many misconceptions and misunderstandings about image analysis that keep researchers and pathologists using inefficient or underperforming solutions in their drug discovery and development workflows.
Learn about the Top 5 Image Analysis Myths and the truth to getting the most out of your research.

Case Study: Unlocking the Secret of Cancer Immunotherapy
In this case study, scientists quantified the immune response with Definiens' image analysis by assessing immune cell quantity and location, termed the Immunoscore, to identify a better predictor of disease-free survival for colorectal cancer patients than traditional TNM tumor staging.
Download the Immunoscore case study to learn more about how the scientists used automated image analysis to assess immune response as a prognostic biomarker and how these results are being validated in a 30-site global clinical study.

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