How We Look at Tissue
Pathologists know there are thousands of features in tissue samples that can be correlated with other data sources. They also know that extracting and quantifying all these features is beyond the scope of what the human eye and mind can do.
Let's have a look at a very relevant example: prostate cancer. Even a complex assessment of H&E stained slides such as the Gleason score for prostate cancer prognosis has constraints: It has been estimated that as many as 70% of patients who receive surgery or radiation therapy for prostate cancer could safely forego these disabling treatments, if correctly stratified.
What is needed is a way to extract information from tissue to reliably discern patients who need immediate therapy from those which could adopt an active monitoring strategy.
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